PLTW Medical Detectives · Lesson 1

Exploring
What's Vital

Activity 1.2 — detectives don't just collect evidence. They run experiments to make more of it.

4 days · You will design and run a real experiment on a real human being (your partner) — and try to lower a vital sign on purpose.
Tap any glowing word for the meaning in English and Spanish.

Do now

How would
you know?

A company says its new medicine treats a disease. A coach says an energy drink makes athletes faster. Your friend says chewing gum helps you focus.

How would you actually find out if any of that is true? Doctors, researchers, and scientists face this question every day — and their answer is to run an experiment and let the data decide.

Think about it: what would you measure, and what would you compare it to? Keep that question in your pocket — it is the whole activity.

The process

Experimental design

Scientists plan experiments with a step-by-step process, so the work is clear, logical, and repeatable — another scientist could run it the exact same way and check the results.

1 · Ask

State a specific, testable question.
"Does 2 minutes of jumping jacks increase respiratory rate?"

2 · Predict

Write a hypothesis — a prediction built on what you already know, not just a hunch.

3 · Design

Pick variables, list materials, note safety, include a control, write numbered steps, plan the data table, use multiple trials.

4 · Run & conclude

Carry it out, record data and observations, look for patterns, then say whether the results support the hypothesis.

Not a strict recipe: real scientists loop back — they change a hypothesis, redesign a flawed procedure, or ask a brand-new question. Going backward is not failing; it is doing science.

Check your understanding

The bean plant experiment

A scientist varies the amount of fertilizer in each pot, then measures the height of each plant after one week and two weeks.

Question 1
What is the dependent variable in this experiment?
Question 2 · Talk first, then reveal
Why is it important for scientists to write clear, step-by-step procedures?
The two variables

Independent vs. dependent

Independent variable

The thing you change on purpose.

Jumping-jacks experiment: doing jumping jacks for two minutes.
Bean plants: the amount of fertilizer.

Dependent variable

The thing you measure — it depends on what you changed.

Jumping jacks: respiratory rate.
Bean plants: the height of the plant.

Memory hook: I change the Independent variable. The Dependent variable Depends on it — that is the one you measure. And test one variable at a time: jumping jacks plus loud music means you cannot tell which one moved the number.

Day 2 · The mission

Can you lower
a vital sign?

In Activity 1.1 you saw what pushes vital signs up: exercise, stress, excitement. But how much control do you have the other way?

Can you make your heart rate or breathing rate go down — on purpose? That is a real, testable question. Today your team designs the experiment that answers it.

Doctors care about this for real: teaching patients to calm their own heart rate is part of treating pain, anxiety, and even heart disease.

Choose your weapons

Pick one of each

A vital sign to measure

Heart rate (beats per minute)
or
Respiratory rate (breaths per minute)

This becomes your dependent variable.

A relaxation technique to test

Slow deep breathing · calm music · eyes closed and still · a gentle stretch · picturing a calm place — or your own idea (cleared by your teacher).

This becomes your independent variable.

One variable at a time: deep breathing with calm music is two experiments mashed together. Pick one thing and test it honestly.

Steps 1 and 2

Your question, your prediction

Research question
Specific and testable. Name the technique AND the vital sign:
"Does ______ (technique) lower ______ (heart rate / respiratory rate)?"
Hypothesis
A confident prediction, built on what you know:
"______ (technique) will lower ______."

Write both on Worksheet 3 — Design. A hypothesis is not a guess — back it with a reason: "because slow breathing signals the body to calm down."

Steps 3 and 4

Variables — and the control

Independent

Your relaxation technique — the thing you change.

Dependent

Your chosen vital sign — the thing you measure.

The control

The resting measurement BEFORE the technique. Without a before-number, an after-number proves nothing.

Notebook question
Which steps in the experiment show how you use a control? Write your answer on Worksheet 3 — Design (and again after the lab on Worksheet 4).

Safety note (yes, even here): only students in good health, with no breathing problems, should be the participant. That line belongs in every design.

Step 4 · The procedure

The experiment, step by step

1
Step 1 of 10
Day 3 · Lab day

Lab briefing

  • Pick roles: one scientist (measures + records), one participant. You will swap if time allows.
  • The participant sits the same way for every trial — same chair, feet down, no talking.
  • Three baseline trials first. No technique until the control numbers are written down.
  • Heart rate: count 15 seconds, then × 4. Breathing: count the full minute — no multiplying. Exactly as in Activity 1.1. You do the math, not the clock.
  • After the technique, measure immediately — calm fades fast.

Safety: only participants in good health, with no breathing problems. Anyone can sit out and be the scientist.

Run it · 3 before, 3 after

Run the experiment

15
seconds

Count beats the whole 15 seconds, then × 4.

1:00
technique

One full minute of your relaxation technique — nothing else.

Trial 1Trial 2Trial 3Average
Before (control)________
After technique________

Record every trial on Worksheet 4 — Lab Data — plus anything you notice (giggling, fidgeting, a door slamming). Observations are data too.

Before you leave

Data check

  • Six measurements written down — three before, three after.
  • Both averages computed (add the three, divide by 3).
  • At least one observation recorded in words.
  • Units on every number — bpm or breaths/min.

No average, no verdict: a single trial can be luck. Three trials and an average is what makes your conclusion trustworthy tomorrow.

Day 4 · Analyze

What did the numbers do?

Compare
Average before vs. average after: did your vital sign go down, up, or stay the same? By how much?
Decide
Do your results support your hypothesis? Say it with the numbers: "Our average dropped from ___ to ___, so..."

If it did not work — you still did science. Scientists change the hypothesis, fix the procedure, or ask a new question. A "no" answered honestly beats a "yes" you cannot trust.

Ethics

The clinical trial question

Clinical trials test new medicines and treatments on real people. In a controlled trial, one group gets the treatment and the control group does not — exactly like your baseline, but with human lives attached.

Discuss · both sides
Should every clinical trial include a control group that does not receive the treatment? What is gained — and what could it cost the people in the control group?

There is no easy answer. Trials are designed to protect participants AND to produce evidence you can trust. Argue both sides before you settle, detective.

Career connection

Research
scientist

Meet Haley Brouwer, a research scientist who develops medical devices. Living with diabetes gave her a passion for building devices that help others. Off the clock: piano, kayaking, and reading.

Experimental design is the shared language of every research job — medicine, food science, sports science, space.

Conclusion

Prove what you learned

Question 1
How might a scientist use experimental design to test the effect of a new medication on an organism that infects humans?
Question 2
How can well-designed experiments help medical detectives solve cases?

Answer like a detective — C.E.R.

Claim — answer in one sentence.
Evidence — use your own experiment: a number, a control, a trial.
Reasoning — connect the evidence to the claim.

Case notes filed

Experiment:
complete

You asked a testable question, predicted, controlled, measured, and concluded from evidence. That is the whole toolkit — and you will use it for the rest of this unit.

Next up: Activity 1.3 — Disease Agents, where the microscopic suspects finally show themselves.

Word Bank · Banco de Palabras

Every academic word in Activity 1.1. Tap one for the full card.

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