PLTW Medical Detectives · Lesson 1

Disease
Diagnosis

Activity 1.4 — a 13-year-old girl is sick after a picnic. You have her medical file, the Disease Dictionary, and a lab. Name the invader.

4 days · Read the file like a detective, narrow the suspects, order a lab test, read the result with controls, and tell the patient what happened.
Tap any glowing word for the meaning in English and Spanish.

Do now · talk with a partner

How does a
doctor know?

You walk into the doctor's office with a stomach ache. Ten minutes later the doctor says what is wrong. How did they figure it out?

Two minutes. List every way a doctor collects clues: things they look at, things they measure, things they ask.

Hint: some clues come from the exam, some from tests — and a surprising number come from questions. Keep your list; you will check it against a real case today.

Diagnostic clues

Doctors are
detectives

When the body is sick, it leaves clues. A doctor is a medical sleuth — a detective who gathers those clues from three places:

  • the physical exam — what the doctor sees, hears, and feels,
  • medical tests — what the lab can measure,
  • and questions — what only the patient can tell them.

This activity is practice for the project coming up, where YOU solve a medical mystery from scratch. Today's patient is fictional. Her clues are not.

Evidence · Patient 1 · September 27
PatientPatient 1 (girl)
Age13
DateSept. 27
Height62 in.
Weight119 lb
TAP EACH VITAL SIGN — normal for a 13-year-old?

Two of these tell one story. Find them before you open the next tab.

Case notes · written by the physician

Patient is a previously healthy 13-year-old girl, brought in by her mother. She says her stomach "hurts in waves" and she feels weak and thirsty.

Two days ago (Saturday, Sept. 25) the family went to a cousin's birthday picnic at the park. She ate grilled chicken, potato salad, deviled eggs, and homemade ice cream. The food sat out on the table through the hot afternoon.

Early the next morning — about 14 hours after the picnic — she woke up with stomach cramps. By breakfast she had watery diarrhea and had vomited twice. She has had a fever since then and has gone to the bathroom "too many times to count." She has not seen any blood.

Her mother says two cousins who ate the same food got sick the same night. Her younger brother, who ate only hot dogs and chips, feels fine. No one at school is sick that she knows of.

The family has not traveled and drinks regular tap water. She has not been around any babies or day-care children. She tries to drink water but "it comes right back up."

Physical exam
  • Abdomen (belly) tender when pressed; loud gurgling bowel sounds; cramping.
  • Lips and tongue dry. Skin on the back of the hand is slow to flatten after a pinch — a sign of dehydration.
  • Dizzy when she stands up.
  • No rash. No spots in the mouth or throat. Throat not red.
  • Lungs clear. Breathing normal.
  • No leg cramps. No blood seen in the stool sample.
Evidence board

Which clues matter?

Tap every clue from the file that helps explain what is making her sick. Then tap Show the detective's board and compare.

Points to the illness Rules suspects OUT Background only

Detective's rule: a clue about when it started, what she ate, and who else got sick is worth more than any single number. Write your list on Worksheet 1 — Diagnostic Clues.

Questions are clues too

What did the doctor ask?

The case notes did not write themselves. Tap every question the physician must have asked to get those notes. Then check.

Case notes

Write it down

On Worksheet 1 — Diagnostic Clues, finish the vital-sign table, list the clues from each tab, and write three questions the doctor asked.

Keep the list organized — by tab, not in a pile. Tomorrow you will use it to cross suspects off one at a time.

Exit ticket: the ONE clue you think matters most, and why.
"The clue that matters most is ______ because ______."

Day 2 · The strategy

Sixteen suspects.
One answer.

The Disease Dictionary lists sixteen illnesses. Guessing is not a strategy. Detectives use a funnel: ask a question that crosses off many suspects at once, then a second, then a third — until one is left.

Every question uses a column of the dictionary: symptoms, incubation period, transmission.

Warm-up first: from memory — what did Patient 1 eat, and how long after did she get sick?

The diagnosis funnel

Ask three questions, in order

Question 1 · symptoms

Do the symptoms match?

Compare her symptoms to the Symptoms of Disease column. Watch for symptoms she does not have, too.

Patient 1: watery diarrhea, vomiting, fever 101.3, cramps, dehydrated. NO blood, NO rash, NO cough.
Question 2 · timing

Does the incubation period fit?

Count from contact to first symptoms. Compare to the Incubation Period column.

Patient 1: picnic Saturday afternoon → cramps early Sunday. About 14 hours — less than one day.
Question 3 · spread

Does the way it spreads fit?

Read the Transmission column. Who else got sick? Any travel? What did she eat, drink, touch?

Patient 1: picnic food left out; cousins who ate it got sick; brother who didn't is fine; no travel; tap water; no babies.

Question 1 alone cuts sixteen suspects to five — the ones whose main symptoms live in the gut. Questions 2 and 3 do the rest.

Five gut suspects · use the dictionary

The suspect board

Suspect 1 · Symptoms match?diarrhea, vomiting, fever 101.3, cramps; no blood 2 · Incubation fits?sick about 14 hours after the picnic 3 · Spread fits?picnic food; cousins sick; no travel; tap water; no babies ✔ total
Tap a suspect’s name to read its Disease Dictionary card here.
✓ or ✗ in every box, then lock in and check:
Step 4 · diagnose

Submit your
diagnosis

On Worksheet 2 — Narrow It Down, fill in the board, then write your diagnosis as a detective would — claim, evidence, reasoning.

  • "I think Patient 1 has ______, caused by a ______ (bacterium / virus)."
  • "The clues that fit are ______, ______, and ______."
  • "I crossed off ______ because ______."

Tomorrow the lab tests your answer. If the test comes back negative, you go back to the clues — that is not failing, that is diagnosing.

Before you leave

One question
did the most work

Which of the three funnel questions crossed off the most suspects for you — symptoms, timing, or spread?

"The ______ question did the most work because it crossed off ______."
Hand it in with Worksheet 2.

Day 3 · I'm positive it's negative

Compared
to what?

In Activities 1.2 and 1.3 you learned that a good experiment needs a control — something to compare against. Lab tests need them too. Every result comes with two controls:

  • A positive control — a sample we know has the disease. It shows what a positive result looks like.
  • A negative control — a sample we know does not. It shows what negative looks like.
  • The patient sample gets compared to both. Match the positive → positive. Match the negative → negative.

Warm-up first: what is the control in an experiment, in one sentence?

Practice · read the lab result

Positive, negative, or broken?

Results for Disease A
The two controls · the answer key
Positive controlknown to HAVE the disease
Negative controlknown NOT to have it
compare
The unknown
Patient sampleWhich control does it match?
0 / 6

Look at the patient sample. Which control does it match?

Round 1 is PLTW's own example (Disease A). The rounds after it get sneakier — including two where the test itself failed.

Why two controls?

When the test
is the problem

If the positive and negative controls come out the same color, the test did not work — maybe the chemicals were old, maybe a step was skipped. The patient's result means nothing that day.

Without controls you would never know. You would read a broken test as a real answer — and treat a patient for the wrong thing.

Same rule as Activity 1.3: if a ring showed up around the plain paper disc, the antibiotic did not deserve the credit. Controls catch the lie.

The lab · Patient 1

Order the test for your diagnosis

Pick the agent you diagnosed. The lab runs the test and hands back the result with both controls. You read it. Every test costs the family money — order the one your evidence points to first.

Tests ordered: 0 · Lab bill: $0

Case notes

Was your
diagnosis right?

On Worksheet 3 — Positive or Negative?, record every test you ordered and what it showed. Then answer honestly:

  • Was your first diagnosis correct? "My first diagnosis was ______. The lab said ______."
  • If not, which clue sent you to a different diagnosis? "I changed to ______ because the clue ______."
  • What is the agent, and what treatment does the dictionary give?

Detectives who changed their answer did real science. The lab did not embarrass them — it gave them evidence.

Day 4 · Connect the vitals

Why her blood pressure was low — and her pulse high

body fluid
Diarrhea + vomiting = fluid lostShe could not keep water down. Her body ran low on fluid — dehydration.
Less fluid → less blood volume → 86/60Less blood in the pipes means less push on the walls. Blood pressure drops. She feels dizzy standing up.
Low pressure → heart speeds up → 105 bpmThe heart beats faster to move the blood that is left. A fast pulse with a low pressure is the dehydration signature.

Warm-up first: her diagnosis, the agent, and how she caught it — from memory. Then: the fever is the infection. The other two numbers are the water.

Treatment · from the Disease Dictionary

Fluids first

The dictionary says: treat the symptoms — fluid and salt replacement. Small sips, often. Broth, an oral rehydration drink, water with a little salt and sugar. Rest. Bland food when she can keep it down.

Antibiotics only for severe cases. Most people with this illness get better in 4 to 7 days without them — and needless antibiotics breed resistance (Activity 1.3).

Red flags that mean "come back now": cannot keep any fluid down, no urine for many hours, blood in the stool, fever climbing past 102.

Communicate · the patient deserves to understand

If you were her physician…

1 · The agent
Name the invader and what kind it is, in words a 13-year-old understands.
"You have ______. It is caused by a ______ called ______."
2 · How it spread
Explain the transmission using HER story.
"You most likely got it from ______ at the picnic, because ______."
3 · Next time
One thing that would have prevented it.
"Next time, ______ so that ______."

Write all three on Worksheet 4 — Treatment & Conclusion. Then say them out loud to your partner as if they were the patient. No scary words, no blame.

Career connection

Not only doctors diagnose

A sick child sees someone in a white coat who examines, asks questions, diagnoses, and writes a prescription. Most people assume it was a doctor. Often it is an advanced practice provider — trained, certified, and licensed to do those things.

Physician assistantExamines, diagnoses, treats, prescribes — works with a physician team.
Nurse practitionerA nurse with advanced training who can diagnose and prescribe.
Nurse midwifeCares for people through pregnancy and birth.
Nurse anesthetistGives the medicine that keeps you asleep and safe during surgery.
Clinical nurse specialistAn expert nurse in one area, like heart care or kids.
Reflect · working together

How did you
work the case?

Real diagnosis is a team sport — nurses, providers, lab techs, and the patient's family all add clues. Talk with your partner, then write:

  • "One thing my partner noticed that I missed was ______."
  • "Working together was / was not helpful because ______."

On Worksheet 4 — Treatment & Conclusion, Part C.

Conclusion

Prove what you learned

Question 1
Why are positive and negative controls important when reading a patient's lab results?
Question 2
If you were Patient 1's physician, what would you tell her about the disease agent that caused the illness and how it was transmitted?

Answer like a detective — C.E.R.

Claim — one sentence. Evidence — a control, a clue from the file, a dictionary fact. Reasoning — connect them.

Both answers go on Worksheet 4 — Treatment & Conclusion, Part D.

Case closed

Patient 1:
diagnosed

You read a medical file, funneled sixteen suspects down to one, ordered a lab test, and read it with controls. That is exactly how a real diagnosis works.

Next up: Project 1.5 — Diagnostic Detectives, where the file is yours to build.

Word Bank · Banco de Palabras

Every academic word in Medical Detectives so far. Tap one for the full card.

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